Strukturell analogi
Inom kemin betecknar en strukturell analog, även känd som kemisk analog eller helt enkelt analog, en förening som har en struktur som liknar den hos en annan förening, men skiljer sig i form av någon "detalj".[1][2][3]
Det kan röra sig om en skillnad på en eller flera atomer, funktionella grupper eller understrukturer som är ersatta med andra atomer, grupper eller understrukturer. En analog kan, åtminstone teoretiskt, bildas från den andra föreningen.
Trots den stora likheten behöver en strukturell analog inte vara en funktionell analog och de kan ha mycket olika fysiska, kemiska, biokemiska eller farmakologiska egenskaper.[4]
Exempel
Referenser
- ^ Willett, Peter, Barnard, John M. and Downs, Geoffry M. (1998). ”Chemical Similarity Searching”. Journal of Chemical Information and Computer Science 38: sid. 983–996. doi:. http://www.cust.edu.tw/mathmet/qsar_ref/Willett_1998.pdf.
- ^ A. M. Johnson, G. M. Maggiora (1990). Concepts and Applications of Molecular Similarity. New York: John Willey & Sons. ISBN 0-471-62175-7
- ^ N. Nikolova, J. Jaworska (2003). ”Approaches to Measure Chemical Similarity - a Review”. QSAR & Combinatorial Science 22 (9-10): sid. 1006–1026. doi:.
- ^ Martin, Yvonne C., Kofron, James L. and Traphagen, Linda M. (2002). ”Do Structurally Similar Molecules Have Similar Biological Activity?”. Journal of Medicinal Chemistry 45 (19): sid. 4350–4358. doi:. PMID 12213076. http://pubs.acs.org/doi/abs/10.1021/jm020155c.
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Amphetamine-2D-skeletal.svg
Amphetamine molecular structure. Methamphetamine has the same structure, with the addition of a methyl group attached to the nitrogen. Molecular structure of racemic amphetamine. Methamphetamine has a similar structure, with the addition of a methyl group bonded to the amine. Amphetamine molecular structure. Methamphetamine has a methyl group attached to the nitrogen. Amphetamine, the prototypical releasing agent, which acts on norepinephrine and dopamine. An example showing a two-dimensional visual representation of the structure of the compound amphetamine, which has the composition C9H13N and a mass of 135.21.
Amphetamine molecular structure. Methamphetamine has the same structure, with the addition of a methyl group attached to the nitrogen. Molecular structure of racemic amphetamine. Methamphetamine has a similar structure, with the addition of a methyl group bonded to the amine. Amphetamine molecular structure. Methamphetamine has a methyl group attached to the nitrogen. Amphetamine, the prototypical releasing agent, which acts on norepinephrine and dopamine. An example showing a two-dimensional visual representation of the structure of the compound amphetamine, which has the composition C9H13N and a mass of 135.21.
Methamphetamine.svg
2D structure of stimulant drug methamphetamine
2D structure of stimulant drug methamphetamine
Essigsäure - Acetic acid.svg
Structure of acetic acid
Structure of acetic acid