Rostrala migrationsbanan
(a) Bild på huvudet av en mus, med rostrala migrationsbanan (RMS) i rött. (b) Migration av nybildade neuroner börjar i laterala ventriklarna (LV), fortsätter längs rostrala migrationsbanan och stannar vid luktbulben (OB) där mogna interneuroner regenereras. (c) Schematisk bild baserad på elektronmikroskopi, som visar cellarkitekturen hos den subventrikulära zonen (SVZ) längs ventrikeln. (d) Schematisk bild av migrationen av nybildade neuroner längs RMS (e) Migration av nybildade neuroner in i luktbulben.
Rostrala migrationsbanan (RMS) är en bana i hjärnan hos en del djur, längs vilken omogna neuroner (stamceller) som uppstod i den subventrikulära zonen (SVZ) av hjärnan migrerar för att nå luktbulben (olfaktoriska bulben), där de sprids i interneuroner. Neurogenes har bevisats inträffa i den subventrikulära zonen även hos vuxna (innan trodde man att hjärnceller inte kunde nybildas i den vuxna hjärnan).
Källor
- H. Troy Ghashghaei, Cary Lai, E. S. Anton. Neuronal migration in the adult brain: are we there yet? Nature Reviews: Neuroscience, Volume 8: 141-151, 2007
- Den här artikeln är helt eller delvis baserad på material från engelskspråkiga Wikipedia, Rostral migratory stream, 7 september 2009.
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Rostral migratory stream mouse.jpg
Författare/Upphovsman: Jessica B Lennington, Zhengang Yang and Joanne C Conover, Licens: CC BY 2.0
(a) Head of a mouse showing the location of the brain and the rostral migratory stream, RMS, (in red) along which newly generated neuroblasts migrate from the SVZ of the lateral ventricle into the olfactory bulb (OB). (b) The migration of newly generated neuroblasts begins at the lateral ventricle, continues along the RMS and terminated in the OB, where mature interneuron populations are generated. (c) Schematic based on electron microscopy showing the cytoarchitecture of the SVZ along the ventricle. Ependymal cells (gray) form a monolayer along the ventricle with astrocytes (green), neuroblasts (red) and transitory amplifying progenitors (TAP) (purple) comprising the SVZ. (d) Schematic showing the migration of neuroblasts along the RMS. Astrocytes (green) ensheath the migrating neuroblasts (red) and are thought to restrict and contain the neuroblasts to their specific pathway. (e) Migrating neuroblasts enter the OB, migrate radially and give rise to granule or periglomerular cells.
Författare/Upphovsman: Jessica B Lennington, Zhengang Yang and Joanne C Conover, Licens: CC BY 2.0
(a) Head of a mouse showing the location of the brain and the rostral migratory stream, RMS, (in red) along which newly generated neuroblasts migrate from the SVZ of the lateral ventricle into the olfactory bulb (OB). (b) The migration of newly generated neuroblasts begins at the lateral ventricle, continues along the RMS and terminated in the OB, where mature interneuron populations are generated. (c) Schematic based on electron microscopy showing the cytoarchitecture of the SVZ along the ventricle. Ependymal cells (gray) form a monolayer along the ventricle with astrocytes (green), neuroblasts (red) and transitory amplifying progenitors (TAP) (purple) comprising the SVZ. (d) Schematic showing the migration of neuroblasts along the RMS. Astrocytes (green) ensheath the migrating neuroblasts (red) and are thought to restrict and contain the neuroblasts to their specific pathway. (e) Migrating neuroblasts enter the OB, migrate radially and give rise to granule or periglomerular cells.