Histoplasmos
Synliga skador på vänstra delen av överläppen, orsakade av Histoplasmos
Mikroskopisk bild av smittämnet, Histoplasma capsulatum
Histoplasmos är en sjukdom som orsakas av svampen Histoplasma capsulatum. Symtomen från denna infektion är mycket varierande, men den påverkar framför allt lungorna.[1] Ibland påverkas andra organ och denna sjukdom kan orsaka döden om den inte behandlas.
Histoplasmos är vanlig bland AIDS-patienter på grund av deras svaga immunsystem.[2] Hos personer med normalt fungerande immunsystem uppstår som en följd av infektionen ett begränsat immunskydd mot skador av efterföljande infektioner.
Histoplasma capsulatum finns i jord, ofta i samband med spillning från fladdermöss eller fåglar. Störning av jorden, som uppkommer till exempel vid grävning eller byggarbete, kan frigöra smittan så att den kan inandas och slå sig ned i lungan.
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Histoplasmosis, due to the fungus Histoplasma capsulatum skin lesion 6840 lores.jpg
This patient presented with a skin lesion on his upper lip. The ulcer was originally thought to be due to a syphilitic infection, but later, after laboratory testing, was diagnosed as histoplasmosis, due to the fungus Histoplasma capsulatum. Skin lesions such as this can be a manifestation of “disseminated histoplasmosis”, referring to the spread of the fungal pathogen, H. capsulatum, throughout the body including the skin, bone marrow, brain and other organs. Disseminated histoplasmosis is most common amongst immunosuppressed people, such as those with AIDS.
This patient presented with a skin lesion on his upper lip. The ulcer was originally thought to be due to a syphilitic infection, but later, after laboratory testing, was diagnosed as histoplasmosis, due to the fungus Histoplasma capsulatum. Skin lesions such as this can be a manifestation of “disseminated histoplasmosis”, referring to the spread of the fungal pathogen, H. capsulatum, throughout the body including the skin, bone marrow, brain and other organs. Disseminated histoplasmosis is most common amongst immunosuppressed people, such as those with AIDS.
Histoplasmosis capsulatum.jpg
Note the histopathologic changes seen in histoplasmosis due to Histoplasma capsulatum using methenamine silver stain. Note the presence of typical yeast cells, some of which are undergoing replication by “budding”. Histoplasmosis can be confined to the lungs, or become systemically disseminated, thereby, producing a fatal outcome.
Note the histopathologic changes seen in histoplasmosis due to Histoplasma capsulatum using methenamine silver stain. Note the presence of typical yeast cells, some of which are undergoing replication by “budding”. Histoplasmosis can be confined to the lungs, or become systemically disseminated, thereby, producing a fatal outcome.