Aspartataminotransferas
Aspartataminotransferas (ASAT) (engelska: Aspartate transaminase (AST)) är ett enzym som har till uppgift att katalysera överföringen av en aminogrupp från aspartat till en ketosyra. ASAT förekommer främst i hjärta, lever och skelettmuskulatur. I levern finns ASAT både i mitokondrier och i cytoplasman till skillnad från ALAT som bara finns i cytoplasman. Vid skador på något av dessa organ kan ASAT mätas i blodet. Mängden ASAT halveras i blodet på ungefär 12 timmar.
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Media som används på denna webbplats
Gallus gallus aspartate aminotransferase dimer.png
Författare/Upphovsman: Deposition authors: Mcphalen, C.A., Vincent, M.G., Jansonius, J.N.;
Visualization author: Synpath, Licens: CC0
Cartoon representation of the Gallus gallus aspartate aminotransferase dimer (PDB: 7AAT). The The lysine-pyridoxal phosphate internal aldimine is shown in black as a ball and stick model, and is found at the interface between the large (blue) and small (red) domains. The N-terminal is highlighted in green.
Författare/Upphovsman: Deposition authors: Mcphalen, C.A., Vincent, M.G., Jansonius, J.N.;
Visualization author: Synpath, Licens: CC0
Cartoon representation of the Gallus gallus aspartate aminotransferase dimer (PDB: 7AAT). The The lysine-pyridoxal phosphate internal aldimine is shown in black as a ball and stick model, and is found at the interface between the large (blue) and small (red) domains. The N-terminal is highlighted in green.
Aspartate aminotransferase reaction.png
Författare/Upphovsman: Benzenamino, Licens: CC BY-SA 3.0
Reaction catalyzed by aspartate aminotransferase: Aspartate + α-ketoglutarate ⇌ oxaloacetate + glutamate; transferred amino group is highlighted in red; created using ACD/ChemSketch v12.01 (freeware version)
Författare/Upphovsman: Benzenamino, Licens: CC BY-SA 3.0
Reaction catalyzed by aspartate aminotransferase: Aspartate + α-ketoglutarate ⇌ oxaloacetate + glutamate; transferred amino group is highlighted in red; created using ACD/ChemSketch v12.01 (freeware version)
2cst.jpg
Författare/Upphovsman: Deposition authors: Malashkevich, V.N., Strokopytov, B.V., Borisov, V.V.;
visualization author: User:Astrojan, Licens: CC BY-SA 4.0
GOT (= Glutamate Oxaloacetate Transaminase) homodimer + 2 PLP (= pyridoxal phosphate, green) + 2 maleic acid (l.blue), Gallus gallus
Författare/Upphovsman: Deposition authors: Malashkevich, V.N., Strokopytov, B.V., Borisov, V.V.;
visualization author: User:Astrojan, Licens: CC BY-SA 4.0
GOT (= Glutamate Oxaloacetate Transaminase) homodimer + 2 PLP (= pyridoxal phosphate, green) + 2 maleic acid (l.blue), Gallus gallus
Aspartate aminotransferase mechanism.png
Författare/Upphovsman: Benzenamino, Licens: CC BY-SA 3.0
Proposed mechanism for the half-reaction catalyzed by aspartate aminotransferase: Enzyme-PLP + aspartate ⇌ Enzyme-PMP + oxaloacetate. Adapted from Kirsch et al. (1984)[1]. Created using ACD/ChemSketch v12.01 (freeware version)
Författare/Upphovsman: Benzenamino, Licens: CC BY-SA 3.0
Proposed mechanism for the half-reaction catalyzed by aspartate aminotransferase: Enzyme-PLP + aspartate ⇌ Enzyme-PMP + oxaloacetate. Adapted from Kirsch et al. (1984)[1]. Created using ACD/ChemSketch v12.01 (freeware version)